000057921 001__ 57921
000057921 005__ 20170504101429.0
000057921 0247_ $$2doi$$a10.1155/2013/603786
000057921 0248_ $$2sideral$$a81878
000057921 037__ $$aART-2013-81878
000057921 041__ $$aeng
000057921 100__ $$aUrrechaga, E.
000057921 245__ $$aBiomarkers of hypochromia: The contemporary assessment of iron status and erythropoiesis
000057921 260__ $$c2013
000057921 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057921 5203_ $$aIron status is the result of the balance between the rate of erythropoiesis and the amount of the iron stores. Direct consequence of an imbalance between the erythroid marrow iron requirements and the actual supply is a reduction of red cell hemoglobin content, which causes hypochromic mature red cells and reticulocytes. The diagnosis of iron deficiency is particularly challenging in patients with acute or chronic inflammatory conditions because most of the biochemical markers for iron metabolism (serum ferritin and transferrin ) are affected by acute phase reaction. For these reasons, interest has been generated in the use of erythrocyte and reticulocyte parameters, available on the modern hematology analyzers. Reported during blood analysis routinely performed on the instrument, these parameters can assist in early detection of clinical conditions (iron deficiency, absolute, or functional; ineffective erythropoiesis, including iron restricted or thalassemia), without additional cost. Technological progress has meant that in recent years modern analyzers report new parameters that provide further information from the traditional count. Nevertheless these new parameters are exclusive of each manufacturer, and they are patented. This is an update of these new laboratory test biomarkers of hypochromia reported by different manufactures, their meaning, and clinical utility on daily practice.
000057921 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057921 590__ $$a0.0$$b2013
000057921 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057921 700__ $$aBorque, L.
000057921 700__ $$0(orcid)0000-0002-6012-7412$$aEscanero, J.F.$$uUniversidad de Zaragoza
000057921 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDepartamento de Farmacología y Fisiología$$cFisiología
000057921 773__ $$g2013 (2013), 603786 [8 pp]$$pBioMed res. int.$$tBioMed Research International$$x2314-6133
000057921 8564_ $$s1178663$$uhttp://zaguan.unizar.es/record/57921/files/texto_completo.pdf$$yVersión publicada
000057921 8564_ $$s94071$$uhttp://zaguan.unizar.es/record/57921/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057921 909CO $$ooai:zaguan.unizar.es:57921$$particulos$$pdriver
000057921 951__ $$a2017-05-04-10:13:44
000057921 980__ $$aARTICLE