000057857 001__ 57857
000057857 005__ 20201105083205.0
000057857 0247_ $$2doi$$a10.1371/journal.pone.0112171
000057857 0248_ $$2sideral$$a88762
000057857 037__ $$aART-2014-88762
000057857 041__ $$aeng
000057857 100__ $$aCabrera, S.
000057857 245__ $$aIntronic variants in the NFKB1 gene may influence hearing forecast in patients with unilateral sensorineural hearing loss in meniere's disease
000057857 260__ $$c2014
000057857 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057857 5203_ $$aMeniere's disease is an episodic vestibular syndrome associated with sensorineural hearing loss (SNHL) and tinnitus. Patients with MD have an elevated prevalence of several autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and psoriasis), which suggests a shared autoimmune background. Functional variants of several genes involved in the NF-¿B pathway, such as REL, TNFAIP3, NFKB1 and TNIP1, have been associated with two or more immune-mediated diseases and allelic variations in the TLR10 gene may influence bilateral affectation and clinical course in MD. We have genotyped 716 cases of MD and 1628 controls by using the ImmunoChip, a high-density genotyping array containing 186 autoimmune loci, to explore the association of immune system related-loci with sporadic MD. Although no single nucleotide polymorphism (SNP) reached a genome-wide significant association (p<10-8), we selected allelic variants in the NF-kB pathway for further analyses to evaluate the impact of these SNPs in the clinical outcome of MD in our cohort. None of the selected SNPs increased susceptibility for MD in patients with uni or bilateral SNHL. However, two potential regulatory variants in the NFKB1 gene (rs3774937 and rs4648011) were associated with a faster hearing loss progression in patients with unilateral SNHL. So, individuals with unilateral MD carrying the C allele in rs3774937 or G allele in rs4648011 had a shorter mean time to reach hearing stage 3 (>40 dB HL) (log-rank test, corrected p values were p¿=¿0.009 for rs3774937 and p¿=¿0.003 for rs4648011, respectively). No variants influenced hearing in bilateral MD. Our data support that the allelic variants rs3774937 and rs4648011 can modify hearing outcome in patients with MD and unilateral SNHL.
000057857 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI13/1242$$9info:eu-repo/grantAgreement/ES/ISCIII/PI09-00920$$9info:eu-repo/grantAgreement/EUR/COST/BM1306-TINNET
000057857 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057857 590__ $$a3.234$$b2014
000057857 591__ $$aMULTIDISCIPLINARY SCIENCES$$b9 / 57 = 0.158$$c2014$$dQ1$$eT1
000057857 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057857 700__ $$aSanchez, E.
000057857 700__ $$aRequena, T.
000057857 700__ $$aMartinez-Bueno, M.
000057857 700__ $$aBenitez, J.
000057857 700__ $$aPerez, N.
000057857 700__ $$aTrinidad, G.
000057857 700__ $$aSoto-Varela, A.
000057857 700__ $$aSantos-Perez, S.
000057857 700__ $$aMartin-Sanz, E.
000057857 700__ $$0(orcid)0000-0002-6561-3305$$aFraile, J.$$uUniversidad de Zaragoza
000057857 700__ $$aPerez, P.
000057857 700__ $$aAlarcon-Riquelme, M.
000057857 700__ $$aBatuecas, A.
000057857 700__ $$aEspinosa-Sanchez, J.
000057857 700__ $$aAran, I.
000057857 700__ $$aLopez-Escamez, J.
000057857 7102_ $$11004$$2653$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Otorrinolaringología
000057857 773__ $$g9, 11 (2014), e112171 [8 pp]$$pPLoS One$$tPloS one$$x1932-6203
000057857 8564_ $$s1166203$$uhttps://zaguan.unizar.es/record/57857/files/texto_completo.pdf$$yVersión publicada
000057857 8564_ $$s126307$$uhttps://zaguan.unizar.es/record/57857/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057857 909CO $$ooai:zaguan.unizar.es:57857$$particulos$$pdriver
000057857 951__ $$a2020-11-05-08:18:06
000057857 980__ $$aARTICLE