000056293 001__ 56293 000056293 005__ 20240124152520.0 000056293 0247_ $$2doi$$a10.3748/wjg.v22.i21.4966 000056293 0248_ $$2sideral$$a94505 000056293 037__ $$aART-2016-94505 000056293 041__ $$aeng 000056293 100__ $$aLue, Alberto 000056293 245__ $$aHow important is donor age in liver transplantation? 000056293 260__ $$c2016 000056293 5060_ $$aAccess copy available to the general public$$fUnrestricted 000056293 5203_ $$aThe age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation (LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Liver Disease, Survival Outcomes Following Liver Transplantation, and the Balance of Risk. The use of old donors is related to an increased rate of biliary complications and hepatitis C virus-related graft failure. Although liver function does not seem to be significantly affected by age, the incidence of several liver diseases increases with age, and the capacity of the liver to manage or overcome liver diseases or external injuries decreases. In this paper, the importance of age in LT outcomes, the role of donor age as a risk factor, and the influence of aging on liver regeneration are reviewed. 000056293 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/ 000056293 590__ $$a3.365$$b2016 000056293 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b29 / 79 = 0.367$$c2016$$dQ2$$eT2 000056293 592__ $$a1.272$$b2016 000056293 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1 000056293 593__ $$aGastroenterology$$c2016$$dQ1 000056293 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000056293 700__ $$0(orcid)0000-0001-8056-5236$$aSolanas, Estela$$uUniversidad de Zaragoza 000056293 700__ $$0(orcid)0000-0002-8969-7726$$aBaptista, Pedro 000056293 700__ $$0(orcid)0000-0003-4672-8083$$aLorente, Sara$$uUniversidad de Zaragoza 000056293 700__ $$0(orcid)0000-0001-6033-2216$$aAraiz, Juan José$$uUniversidad de Zaragoza 000056293 700__ $$0(orcid)0000-0002-8275-7191$$aGarcía-Gil, Agustín$$uUniversidad de Zaragoza 000056293 700__ $$0(orcid)0000-0002-7119-2244$$aSerrano, María Trinidad$$uUniversidad de Zaragoza 000056293 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología 000056293 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000056293 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía 000056293 773__ $$g22, 21 (2016), 4966-4976$$tWorld Journal of Gastroenterology$$x1007-9327 000056293 8564_ $$s1043606$$uhttps://zaguan.unizar.es/record/56293/files/texto_completo.pdf$$yVersión publicada 000056293 8564_ $$s66227$$uhttps://zaguan.unizar.es/record/56293/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000056293 909CO $$ooai:zaguan.unizar.es:56293$$particulos$$pdriver 000056293 951__ $$a2024-01-24-15:16:31 000056293 980__ $$aARTICLE