000056142 001__ 56142
000056142 005__ 20170503140336.0
000056142 0247_ $$2doi$$a10.1016/j.ejpb.2015.08.007
000056142 0248_ $$2sideral$$a92007
000056142 037__ $$aART-2015-92007
000056142 041__ $$aeng
000056142 100__ $$aGimeno, M.
000056142 245__ $$aA controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study
000056142 260__ $$c2015
000056142 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056142 5203_ $$aA new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin.
000056142 536__ $$9info:eu-repo/grantAgreement/EUR/FP7/ERC2013-CoG-614715
000056142 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000056142 590__ $$a3.975$$b2015
000056142 591__ $$aPHARMACOLOGY & PHARMACY$$b44 / 255 = 0.173$$c2015$$dQ1$$eT1
000056142 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056142 700__ $$aPinczowski, P.
000056142 700__ $$0(orcid)0000-0002-8133-2124$$aPérez, M.$$uUniversidad de Zaragoza
000056142 700__ $$aGiorello, A.
000056142 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, M.Á.$$uUniversidad de Zaragoza
000056142 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, J.$$uUniversidad de Zaragoza
000056142 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000056142 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, L.$$uUniversidad de Zaragoza
000056142 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDepartamento de Patología Animal$$cSanidad Animal
000056142 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDepartamento de Ingeniería Química y Tecnologías del Medio Ambiente$$cIngeniería Química
000056142 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDepartamento de Anatomía, Embriología y Genética Animal$$cAnatomía y Anatomía Patológica Comparadas
000056142 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDepartamento de Ingeniería Mecánica$$cMec. de Medios Contínuos y Teor. de Estructuras
000056142 773__ $$g96 (2015), 264-271$$pEur. j. pharm. biopharm.$$tEUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS$$x0939-6411
000056142 8564_ $$s1218256$$uhttp://zaguan.unizar.es/record/56142/files/texto_completo.pdf$$yVersión publicada
000056142 8564_ $$s112776$$uhttp://zaguan.unizar.es/record/56142/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000056142 909CO $$ooai:zaguan.unizar.es:56142$$particulos$$pdriver
000056142 951__ $$a2017-05-03-13:58:05
000056142 980__ $$aARTICLE