000048304 001__ 48304
000048304 005__ 20170327111931.0
000048304 0247_ $$2doi$$a10.3389/fonc.2014.00014
000048304 0248_ $$2sideral$$a86987
000048304 037__ $$aART-2014-86987
000048304 041__ $$aeng
000048304 100__ $$aSchoorlemmer, J.
000048304 245__ $$aRegulation of mouse retroelement MuERV-L/MERVL expression by REX1 and epigenetic control of stem cell potency
000048304 260__ $$c2014
000048304 5060_ $$aAccess copy available to the general public$$fUnrestricted
000048304 5203_ $$aAbout half of the mammalian genome is occupied by DNA sequences that originate from transposable elements. Retrotransposons can modulate gene expression in different ways and, particularly retrotransposon-derived long terminal repeats, profoundly shape expression of both surrounding and distant genomic loci. This is especially important in pre-implantation development, during which extensive reprograming of the genome takes place and cells pass through totipotent and pluripotent states. At this stage, the main mechanism responsible for retrotransposon silencing, i.e., DNA methylation, is inoperative. A particular retrotransposon called muERV-L/MERVL is expressed during pre-implantation stages and contributes to the plasticity of mouse embryonic stem cells. This review will focus on the role of MERVL-derived sequences as controlling elements of gene expression specific for pre-implantation development, two-cell stage-specific gene expression, and stem cell pluripotency, the epigenetic mechanisms that control their expression, and the contributions of the pluripotency marker REX1 and the related Yin Yang 1 family of transcription factors to this regulation process.
000048304 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI07119$$9info:eu-repo/grantAgreement/ES/DGA/PI110-09
000048304 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000048304 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000048304 700__ $$aPérez-Palacios, R.
000048304 700__ $$0(orcid)0000-0002-0606-0763$$aCliment, M.$$uUniversidad de Zaragoza
000048304 700__ $$aGuallar, D.
000048304 700__ $$0(orcid)0000-0003-2014-2869$$aMuniesa, P.$$uUniversidad de Zaragoza
000048304 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDepartamento de Anatomía, Embriología y Genética Animal$$cAnatomía y Anatomía Patológica Comparadas
000048304 773__ $$g4 (2014), A.14 [18 p.]$$pFront. oncol.$$tFrontiers in Oncology$$x2234-943X
000048304 8564_ $$s1575165$$uhttp://zaguan.unizar.es/record/48304/files/texto_completo.pdf$$yVersión publicada
000048304 8564_ $$s124712$$uhttp://zaguan.unizar.es/record/48304/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000048304 909CO $$ooai:zaguan.unizar.es:48304$$particulos$$pdriver
000048304 951__ $$a2016-07-14-10:19:44
000048304 980__ $$aARTICLE