000047854 001__ 47854
000047854 005__ 20170327111845.0
000047854 0247_ $$2doi$$a10.1167/iovs.15-17257
000047854 0248_ $$2sideral$$a92496
000047854 037__ $$aART-2015-92496
000047854 041__ $$aeng
000047854 100__ $$0(orcid)0000-0002-9250-9060$$aSegura, Francisco$$uUniversidad de Zaragoza
000047854 245__ $$aAssessment of Visual and Chromatic Functions in a Rodent Model of Retinal Degeneration
000047854 260__ $$c2015
000047854 5060_ $$aAccess copy available to the general public$$fUnrestricted
000047854 5203_ $$aPurpose: We evaluated the photoreceptor response of pigmented P23H and normal pigmented Long Evans (LE) rats over time using functional tests in variable lighting conditions.

Methods: Pigmented P23H rats were studied by optomotor testing and electroretinogram (ERG) recordings at P30, P150, and P240. Pigmented LE rats were used as a normal wild-type control. Stimuli were modified with colored filters. Neutral density filters were used to reduce luminance.

Results: Age-related decreases in visual acuity (VA) and contrast sensitivity (CS) were observed in P23H rats. Good correlations in measurements without filter and with green filter were observed between LE and P23H P30 rat values. Differences between groups were smaller with red and purple filters. A strong relationship with luminance was observed in LE rats (VA and CS) and with P23H P30 rats (CS). A decline in the ERG responses of P23H rats was consistent with the gradual loss of photoreceptors. Differences in a- and b-wave amplitudes with different colored filters were negligible with the exception of the red filter, which resulted in smaller responses.

Conclusions: Visual function parameters decreased with age in pigmented P23H rats. Irrespective of luminance, color filter, and retinal degeneration, minimum thresholds of VA and CS were found. Smaller differences than expected were found using color filters. Responses to functional tests at long wavelengths were observed, where there is very low photoreceptor spectral sensitivity. The use of filters with functional testing could minimize light-induced retinal damage in rats.
000047854 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0034-0010$$9info:eu-repo/grantAgreement/ES/ISCIII/PS090-1854$$9info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124$$9info:eu-repo/grantAgreement/ES/DGA/B99
000047854 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000047854 590__ $$a3.427$$b2015
000047854 591__ $$aOPHTHALMOLOGY$$b6 / 56 = 0.107$$c2015$$dQ1$$eT1
000047854 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000047854 700__ $$0(orcid)0000-0002-5621-1937$$aSanchez-Cano, Ana$$uUniversidad de Zaragoza
000047854 700__ $$0(orcid)0000-0002-2523-8598$$aJarabo Lallana, Sebastián$$uUniversidad de Zaragoza
000047854 700__ $$0(orcid)0000-0002-7471-5362$$aLopez de la Fuente, Carmen$$uUniversidad de Zaragoza
000047854 700__ $$aCuenca, Nicolas
000047854 700__ $$aVillegas-Perez, Maria P
000047854 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000047854 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDepartamento de Cirugía, Ginecología y Obstetricia$$cOftalmología
000047854 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDepartamento de Física Aplicada$$cOptica
000047854 773__ $$g56, 11 (2015), 6275-6283$$pInvestig. ophthalmol. vis. sci.$$tINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE$$x0146-0404
000047854 8564_ $$s1120703$$uhttp://zaguan.unizar.es/record/47854/files/texto_completo.pdf$$yPostprint
000047854 8564_ $$s122724$$uhttp://zaguan.unizar.es/record/47854/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000047854 909CO $$ooai:zaguan.unizar.es:47854$$particulos$$pdriver
000047854 951__ $$a2017-01-03-12:05:11
000047854 980__ $$aARTICLE