000032187 001__ 32187
000032187 005__ 20170327111918.0
000032187 0247_ $$2doi$$a10.1242/dmm.021774
000032187 0248_ $$2sideral$$a92187
000032187 037__ $$aART-2015-92187
000032187 041__ $$aeng
000032187 100__ $$0(orcid)0000-0002-4379-1100$$aLlobet, Laura$$uUniversidad de Zaragoza
000032187 245__ $$aXenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood
000032187 260__ $$c2015
000032187 5060_ $$aAccess copy available to the general public$$fUnrestricted
000032187 5203_ $$aAdipogenesis is accompanied by differentiation of adipose tissuederived stem cells to adipocytes. As part of this differentiation, biogenesis of the oxidative phosphorylation system occurs. Many chemical compounds used in medicine, agriculture or other human activities affect oxidative phosphorylation function. Therefore, these xenobiotics could alter adipogenesis. We have analyzed the effects on adipocyte differentiation of some xenobiotics that act on the oxidative phosphorylation system. The tested concentrations have been previously reported in human blood. Our results show that pharmaceutical drugs that decrease mitochondrial DNA replication, such as nucleoside reverse transcriptase inhibitors, or inhibitors of mitochondrial protein synthesis, such as ribosomal antibiotics, diminish adipocyte differentiation and leptin secretion. By contrast, the environmental chemical pollutant tributyltin chloride, which inhibits the ATP synthase of the oxidative phosphorylation system, can promote adipocyte differentiation and leptin secretion, leading to obesity and metabolic syndrome as postulated by the obesogen hypothesis.
000032187 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI14-00005$$9info:eu-repo/grantAgreement/ES/FIS/PI14-00070$$9info:eu-repo/grantAgreement/ES/IACS/PIPAMER-09-01$$9info:eu-repo/grantAgreement/ES/IACS/PIPAMER-10-010
000032187 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000032187 590__ $$a4.316$$b2015
000032187 591__ $$aPATHOLOGY$$b10 / 78 = 0.128$$c2015$$dQ1$$eT1
000032187 591__ $$aCELL BIOLOGY$$b59 / 187 = 0.316$$c2015$$dQ2$$eT1
000032187 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000032187 700__ $$0(orcid)0000-0002-7243-1737$$aToivonen, Janne M$$uUniversidad de Zaragoza
000032187 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya, Julio$$uUniversidad de Zaragoza
000032187 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini, Eduardo$$uUniversidad de Zaragoza
000032187 700__ $$0(orcid)0000-0002-3217-1424$$aLópez-Gallardo, Ester$$uUniversidad de Zaragoza
000032187 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDepartamento de Anatomía e Histología Humanas$$cHistología
000032187 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDepartamento de Bioquímica y Biología Molecular y Celular$$cBioquímica y Biología Molecular
000032187 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDepartamento de Anatomía, Embriología y Genética Animal$$cGenética
000032187 773__ $$g8 (2015), 1441-1455$$pDisease Models & Mechanisms$$tDisease Models & Mechanisms$$x1754-8403
000032187 8564_ $$s1680793$$uhttp://zaguan.unizar.es/record/32187/files/texto_completo.pdf$$yVersión publicada
000032187 8564_ $$s137300$$uhttp://zaguan.unizar.es/record/32187/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000032187 909CO $$ooai:zaguan.unizar.es:32187$$particulos$$pdriver
000032187 951__ $$a2016-06-27-11:21:05
000032187 980__ $$aARTICLE